Imidazole → 3-(1H-Imidazol-1-yl)-2-methylpropan-1-amine
Reaktionsgleichung
[NH:1]1[CH:5]=[CH:4][N:3]=[CH:2]1.[C:6](#[N:10])[C:7]([CH3:9])=[CH2:8]>>[N:1]1([CH2:8][CH:7]([CH3:9])[CH2:6][NH2:10])[CH:5]=[CH:4][N:3]=[CH:2]1Komponenten
3
Versuchsvorschrift
A mixture of 15.0 g. of imidazole and 25 ml. of methacrylonitrile was heated at reflux temperature for 18 hours and then concentrated to remove the volatile material. The residue was mixed with 150 ml. of ethanol, 75 ml. of ammonium hydroxide and 6 g. of Raney Nickel catalyst and reduced in a Parr hydrogenator under hydrogen pressure until reduction was complete. The catalyst was removed by filtration and the mother liquor was concentrated to remove the solvents. The residual oil was used in reactions without further purification.
Aufarbeitung
- additionA mixture of 15.0 g
- temperatureat reflux temperature for 18 hours
- concentrationconcentrated
- customto remove the volatile material
- additionThe residue was mixed with 150 ml
- customThe catalyst was removed by filtration
- concentrationthe mother liquor was concentrated
- customto remove the solvents
- customThe residual oil was used in reactions without further purification
Quellen und Nachweise
- ORD-Eintrag
- ord-8a5cb7a754324781a6438db3b65fd06d
- Quelldatensatz
- uspto-grants-1986_02
- Patentnummer
- US04568687
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