Ammonia → 3-Amino-6-(3-trifluoromethylphenyl)pyridazine

HRID 1589466Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1589466
Cl[C:2]1[N:3]=[N:4][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([C:14]([F:17])([F:16])[F:15])[CH:9]=2)=[CH:6][CH:7]=1.[NH3:18]>>[NH2:18][C:2]1[N:3]=[N:4][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([C:14]([F:17])([F:16])[F:15])[CH:9]=2)=[CH:6][CH:7]=1

Komponenten

3

Edukt 2

HCID 222Ammonia2×HCID 124495523-Chloro-6-[3-(trifluoromethyl)phenyl]pyridazine

Produkt 1

HCID 135653673-Amino-6-(3-trifluoromethylphenyl)pyridazine

Reaktionsbedingungen

Temperatur
200 °C

Versuchsvorschrift

A 12.5 g sample of 3-chloro-6-[3-(trifluoromethyl)phenyl]pyridazine was placed in a steel cylinder with liquid ammonia and the sealed cylinder (bomb) was heated at 200° C. The chilled cylinder was opened and the ammonia allowed to evaporate. The solid residue was heated and stirred with chloroform, then filtered. The filtrate was concentrated and the residue recrystallized, first from chloroform-hexane, then twice from chloroform to give 1.8 g of 3-amino-6-[3-(trifluoromethyl)phenyl]pyridazine as white crystals, mp 143°-145° C.

Aufarbeitung

  1. customto evaporate
  2. temperatureThe solid residue was heated
  3. filtrationfiltered
  4. concentrationThe filtrate was concentrated
  5. customthe residue recrystallized, first from chloroform-hexane

Quellen und Nachweise

ORD-Eintrag
ord-249344310eed46bab2a8f1c73e2d6122
Quelldatensatz
uspto-grants-1986_02
Patentnummer
US04569934

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