Hydrochloric Acid → 4-Hydroxy-3-nitrobenzene-1-carboximidamide

HRID 1589492

Reaktionsgleichung

Reaktionsgleichung von HRID 1589492
Cl.[C:2]([C:5]1[CH:10]=[CH:9][C:8]([OH:11])=[CH:7][CH:6]=1)(=[NH:4])[NH2:3].Cl.[N+:13]([O-])([OH:15])=[O:14].C(=O)([O-])O.[Na+]>S(=O)(=O)(O)O>[C:2]([C:5]1[CH:10]=[CH:9][C:8]([OH:11])=[C:7]([N+:13]([O-:15])=[O:14])[CH:6]=1)(=[NH:3])[NH2:4]

Komponenten

6

Edukt 4

HCID 313Hydrochloric AcidHCID 944Nitric AcidHCID 217124Benzenecarboximidamide, 4-hydroxy-, hydrochloride (1:1)HCID 516892Sodium Bicarbonate

Produkt 1

HCID 1355987304-Hydroxy-3-nitrobenzene-1-carboximidamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1118Sulfuric AcidLösungsmittel

Versuchsvorschrift

To 20 ml of concentrated sulfuric acid, was added 7.6 g of 4-amidinophenol hydrochloride. When the evolution of hydrogen chloride gas had ceased, the solution was cooled in an ice-salt bath and 3.0 ml of nitric acid was slowly added to the solution while being stirred. The mixture was then stirred at room temperature for 20 to 30 minutes. The reaction mixture, orange in color, was diluted by pouring into a large volume of ice water. The diluted solution was added in small portions to a saturated aqueous sodium hydrogencarbonate solution to precipitate orange needle crystals. The crystals were collected by filtration and dried to obtain 7.6 g of 4-amidino-2-nitrophenol.

Aufarbeitung

  1. temperaturethe solution was cooled in an ice-salt bath
  2. stirringThe mixture was then stirred at room temperature for 20 to 30 minutes
  3. additionThe reaction mixture, orange in color, was diluted
  4. customto precipitate orange needle crystals
  5. filtrationThe crystals were collected by filtration
  6. customdried

Quellen und Nachweise

ORD-Eintrag
ord-ae7870d0e5ff47f69ab62f88b3a79180
Quelldatensatz
uspto-grants-1986_02
Patentnummer
US04570006

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