HCID 19100959, Verbindung → 5-Chloro-2,3-dimethyl-2,7-diazabicyclo[3.3.0]octane

HRID 1590141Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1590141
[Cl:1][C:2]12[CH2:9][N:8](C(OCC)=O)[CH2:7][CH:6]1[N:5]([CH3:15])[CH:4]([CH3:16])[CH2:3]2>Cl>[Cl:1][C:2]12[CH2:9][NH:8][CH2:7][CH:6]1[N:5]([CH3:15])[CH:4]([CH3:16])[CH2:3]2

Komponenten

3

Edukt 1

HCID 19100959HCID 19100959, Verbindung

Produkt 1

HCID 191009535-Chloro-2,3-dimethyl-2,7-diazabicyclo[3.3.0]octane

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 313Hydrochloric AcidLösungsmittel

Versuchsvorschrift

7.6 g (30.8 mmol) of ethyl 5-chloro-2,3-dimethyl-2,7-diazabicyclo[3.3.0]octane-7-carboxylate together with 30 ml of concentrated hydrochloric acid are refluxed overnight. The mixture is concentrated, the concentrate is taken up in 30 ml of water, this mixture is rendered alkaline using potassium carbonate and extracted five times using 50 ml portions of chloroform, and the extracts are dried over potassium carbonate, concentrated and distilled.

Aufarbeitung

  1. concentrationThe mixture is concentrated
  2. extractionextracted five times
  3. dry with materialthe extracts are dried over potassium carbonate
  4. concentrationconcentrated
  5. distillationdistilled

Quellen und Nachweise

ORD-Eintrag
ord-d240346758624e2d8ec55f8e8f4a3a77
Quelldatensatz
uspto-grants-1993_04
Patentnummer
US05202337

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