Sodium Hydroxide → sodium (S)-2-benzyl-3-(cis-hexahydro-2-isoindolinylcarbonyl)propionate monohydrate

HRID 1590190Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1590190
[CH2:1]([C@@H:8]([CH2:12][C:13]([N:15]1[CH2:23][C@H:22]2[C@H:17]([CH2:18][CH2:19][CH2:20][CH2:21]2)[CH2:16]1)=[O:14])[C:9]([OH:11])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[Na+:25]>C(O)C>[OH2:10].[CH2:1]([C@@H:8]([CH2:12][C:13]([N:15]1[CH2:16][C@H:17]2[C@H:22]([CH2:21][CH2:20][CH2:19][CH2:18]2)[CH2:23]1)=[O:14])[C:9]([O-:11])=[O:10])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1.[Na+:25]

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 121891Mitiglinide

Produkt 1

HCID 67758743sodium (S)-2-benzyl-3-(cis-hexahydro-2-isoindolinylcarbonyl)propionate monohydrate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

To a solution of (S)-2-benzyl-3-(cis-hexahydro-2-isoindolinylcarbonyl)propionic acid (1.38 g) in ethanol (5 ml) was added 2N sodium hydroxide solution (2.19 ml). After the solvent was evaporated under reduced pressure, the residue was crystallized from ethyl acetate to give 1.44 g of sodium (S)-2-benzyl-3-(cis-hexahydro-2-isoindolinylcarbonyl)propionate monohydrate.

Aufarbeitung

  1. customAfter the solvent was evaporated under reduced pressure
  2. customthe residue was crystallized from ethyl acetate

Quellen und Nachweise

ORD-Eintrag
ord-84ea975f100642eaa913f532cc042a2e
Quelldatensatz
uspto-grants-1993_04
Patentnummer
US05202335

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