Reaktionsgleichung
Br[CH:2]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[Cl:12])[C:3]([OH:5])=[O:4].S(=O)(=O)(O)O.[S:18]1[CH:22]=[CH:21][CH:20]=[C:19]1[CH2:23][CH2:24][NH2:25].[CH3:26]O>>[S:18]1[CH:22]=[CH:21][CH:20]=[C:19]1[CH2:23][CH2:24][NH:25][CH:2]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[Cl:12])[C:3]([O:5][CH3:26])=[O:4]Komponenten
Reaktionsbedingungen
- Temperatur
- 30 °C
Versuchsvorschrift
543 g of alpha-bromo(2-chlorophenyl)acetic acid and 30 g of concentrated sulphuric acid are introduced into 300 ml methanol. The mixture is refluxed for 3 hours and, after it has cooled to about 30° C., 230 g of KHCO3 and 265 g of 2-(2-thienyl)ethylamine are added progressively. The mixture is refluxed for 1 hour 30 min and the solvent is then evaporated off under vacuum. 1 l of water and 1 l of ethyl acetate are poured onto the residue and the organic phase is separated off after stirring and phase separation. 300 ml of ice and 180 ml of concentrated hydrochloric acid are then introduced into it. The precipitated product is filtered off and dried. 641 g of the hydrochloride of the required product, which melts at 175° C., are thus obtained.
Aufarbeitung
- temperatureThe mixture is refluxed for 3 hours
- temperatureThe mixture is refluxed for 1 hour 30 min
- customthe solvent is then evaporated off under vacuum
- addition1 l of water and 1 l of ethyl acetate are poured onto the residue
- customthe organic phase is separated off
- customphase separation
- addition300 ml of ice and 180 ml of concentrated hydrochloric acid are then introduced into it
- filtrationThe precipitated product is filtered off
- customdried
Quellen und Nachweise
- ORD-Eintrag
- ord-732095519d85467289fde65ac2fbcb5b
- Quelldatensatz
- uspto-grants-1993_04
- Patentnummer
- US05204469
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