N-(tert-Butyloxycarbonyl)glycine N-hydroxysuccinimide ester → HCID 15940113, Verbindung

HRID 1590985Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1590985
[NH:1]([C:14]([O:16]C(C)(C)C)=O)[C@H:2]([C:7]([NH:9][CH2:10][C:11]([OH:13])=[O:12])=[O:8])[CH2:3][CH:4]([CH3:6])[CH3:5].[NH:21]([C:33]([O:35][C:36]([CH3:39])([CH3:38])[CH3:37])=[O:34])[CH2:22]C(ON1C(=O)CCC1=O)=O>>[NH:21]([C:33]([O:35][C:36]([CH3:39])([CH3:38])[CH3:37])=[O:34])[CH2:22][C:14]([NH:1][C@H:2]([C:7]([NH:9][CH2:10][C:11]([OH:13])=[O:12])=[O:8])[CH2:3][CH:4]([CH3:5])[CH3:6])=[O:16]

Komponenten

3

Edukt 2

HCID 76926N-(tert-Butyloxycarbonyl)glycine N-hydroxysuccinimide esterHCID 7018768(S)-2-(2-((tert-Butoxycarbonyl)amino)-4-methylpentanamido)acetic acid

Produkt 1

HCID 15940113HCID 15940113, VerbindungAusbeute 61,4 %

Versuchsvorschrift

By using 6.41 g of Boc-Leu-Gly-OH and 6.04 g of Boc-Gly-OSu, and the same procedure as in Reference Example 31 was repaeted to obtain 4.67 g (yield: 61.4%) of the above-mentioned objective product.

Quellen und Nachweise

ORD-Eintrag
ord-dc58cf6dbd2347cdbc0bfc92af10d6c6
Quelldatensatz
uspto-grants-1993_04
Patentnummer
US05204326

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