Chloroacetone → 2-Thiophenecarboxylic acid, 5-acetyl-4-hydroxy-, methyl ester
Reaktionsgleichung
Cl[CH2:2][C:3](=[O:5])[CH3:4].[C:6]([C:12]([O:14][CH3:15])=[O:13])#[C:7][C:8](OC)=[O:9].[SH-:16].[Na+]>>[C:3]([C:2]1[S:16][C:6]([C:12]([O:14][CH3:15])=[O:13])=[CH:7][C:8]=1[OH:9])(=[O:5])[CH3:4]Komponenten
4
Versuchsvorschrift
According to the description in Synth. Commun., 1996, 26, 1083, methyl 2-acetyl-3-hydroxythiophene-5-carboxylate was synthesized with chloroacetone, dimethyl acetylene dicarboxylate and sodium hydrosulfide as starting materials (yield: 60%).
Quellen und Nachweise
- ORD-Eintrag
- ord-ecc73145941641afa70ccfc6f141ecaa
- Quelldatensatz
- uspto-grants-2007_11
- Patentnummer
- US07291449B2
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