Sodium Hydroxide → 2-Acetyl-3-hydroxythiophene
Reaktionsgleichung
[C:1]([C:4]1[S:5][C:6](C(OC)=O)=[CH:7][C:8]=1[OH:9])(=[O:3])[CH3:2].[OH-].[Na+]>[Cu].N1C2C(=CC=CC=2)C=CC=1>[C:1]([C:4]1[S:5][CH:6]=[CH:7][C:8]=1[OH:9])(=[O:3])[CH3:2]Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
The above-obtained methyl 2-acetyl-3-hydroxythiophene-5-carboxylate was hydrolyzed with an aqueous solution of sodium hydroxide, the hydrolyzate was heated with copper-quinoline to be decarboxylated, thereby the objective 2-acetyl-3-hydroxythiophene was obtained (yield: 58%).
Quellen und Nachweise
- ORD-Eintrag
- ord-a347ccf5ee2649d3adda0b8311740e3e
- Quelldatensatz
- uspto-grants-2007_11
- Patentnummer
- US07291449B2
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