Triethylamine → Allyl(cyclopentyl)carbamoyl chloride

HRID 1591662Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1591662
[Cl:1][C:2]([O:5]C=O)(Cl)Cl.[CH2:8]([NH:11][CH:12]1[CH2:16][CH2:15][CH2:14][CH2:13]1)[CH:9]=[CH2:10].C(N(CC)CC)C>ClCCl>[CH2:8]([N:11]([CH:12]1[CH2:16][CH2:15][CH2:14][CH2:13]1)[C:2]([Cl:1])=[O:5])[CH:9]=[CH2:10]

Komponenten

5

Edukt 3

HCID 8471TriethylamineHCID 5062349N-(prop-2-en-1-yl)cyclopentanamineHCID 13647314Trichloromethylformate

Produkt 1

HCID 21956032Allyl(cyclopentyl)carbamoyl chloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

790 mg (0.48 ml, 3.99 mmol) of trichloromethylformate (“diphosgene”) are dissolved in 15 ml of dichloromethane and cooled to 0° C. To this are slowly added dropwise 1.00 g (1.17 ml, 7.986 mmol) of allyl(cyclopentyl)amine and 1.21 g (1.67 ml, 12.0 mmol) of triethylamine, and the mixture is left to stir at room temperature overnight. For workup, the reaction solution is poured into ice-water, extracted three times with dichloromethane, dried over MgSO4 and concentrated. The crude product is employed directly in the next stage.

Aufarbeitung

  1. waitthe mixture is left
  2. extractionextracted three times with dichloromethane
  3. dry with materialdried over MgSO4
  4. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-6dae239c627348fab6d49a6775f928d6
Quelldatensatz
uspto-grants-2007_11
Patentnummer
US07291622B2

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