Sodium hydride → 4-Chloro-6-(2,3-dimethylcyclohexyloxy)pyrimidine

HRID 1592283Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1592283
[H-].[Na+].[CH3:3][CH:4]1[CH:9]([CH3:10])[CH2:8][CH2:7][CH2:6][CH:5]1[OH:11].[Cl:12][C:13]1[CH:18]=[C:17](Cl)[N:16]=[CH:15][N:14]=1.[Cl-].[NH4+]>O1CCCC1>[Cl:12][C:13]1[CH:18]=[C:17]([O:11][CH:5]2[CH2:6][CH2:7][CH2:8][CH:9]([CH3:10])[CH:4]2[CH3:3])[N:16]=[CH:15][N:14]=1

Komponenten

6

Edukt 4

HCID 24758Sodium hydrideHCID 25517Ammonium ChlorideHCID 709434,6-DichloropyrimidineHCID 1026312,3-Dimethylcyclohexan-1-ol

Produkt 1

HCID 225997134-Chloro-6-(2,3-dimethylcyclohexyloxy)pyrimidineAusbeute 89,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel3×

Versuchsvorschrift

In 5 ml of tetrahydrofuran was suspended 0.19 g of sodium hydride (60% in oil), to which 0.5 ml of a tetrahydrofuran solution containing 0.48 g of 2,3-dimethylcyclohexanol (mixture of isomers) was slowly added dropwise with stirring at room temperature. The mixture was stirred at room temperature for 10 minutes and then cooled to 0° C., to which 1.5 ml of a tetrahydrofuran solution containing 0.5 g of 4,6-dichloropyrimidine was slowly added dropwise, followed by further stirring at room temperature for 3 hours. The reaction mixture was then poured into a saturated aqueous ammonium chloride solution and extracted three times with t-butyl methyl ether. The organic layers were combined, washed with brine, dried over anhydrous magnesium sulfate, and then concentrated. The residue was subjected to silica gel column chromatography to give 0.72 g of 4-chloro-6-(2,3-dimethylcyclohexyloxy)pyrimidine.

Aufarbeitung

  1. additionwas slowly added dropwise
  2. stirringThe mixture was stirred at room temperature for 10 minutes
  3. additionwas slowly added dropwise
  4. stirringby further stirring at room temperature for 3 hours
  5. extractionextracted three times with t-butyl methyl ether
  6. washwashed with brine
  7. dry with materialdried over anhydrous magnesium sulfate
  8. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-6b50a9e96544424e8da049097dbd3eea
Quelldatensatz
uspto-grants-2007_11
Patentnummer
US07291730B2

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