Hydrochloric Acid → 3-((3-Bromophenyl)thio)propanoic acid

HRID 1593031Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1593031
[Br:1][C:2]1[CH:3]=[C:4]([S:8][CH2:9][CH2:10][C:11]([O:13]CC)=[O:12])[CH:5]=[CH:6][CH:7]=1.[OH-].[Na+].Cl>C(O)C>[Br:1][C:2]1[CH:3]=[C:4]([S:8][CH2:9][CH2:10][C:11]([OH:13])=[O:12])[CH:5]=[CH:6][CH:7]=1

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 62805311Ethyl 3-[(3-bromophenyl)thio]propanoate

Produkt 1

HCID 186867493-((3-Bromophenyl)thio)propanoic acidAusbeute 37,6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Reaktionsbedingungen

Temperatur
20 °C

Versuchsvorschrift

A solution of ethyl 3-[(3-bromophenyl)thio]propanoate (1.15 g) in ethanol (5 ml) was treated with aqueous sodium hydroxide solution (2M, 5 ml) and the mixture was stirred at 20° C. for 15 h. The mixture was acidified with hydrochloric acid and the solution was extracted with ethyl acetate. The organic solution was washed with hydrochloric acid, brine, dried (MgSO4), and evaporated to give the title compound (390 mg) LCMS RT=3.19 min

Aufarbeitung

  1. extractionthe solution was extracted with ethyl acetate
  2. washThe organic solution was washed with hydrochloric acid, brine
  3. dry with materialdried (MgSO4)
  4. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-44c0eb05cb734f3f88b19ebbeb7929ba
Quelldatensatz
uspto-grants-2007_11
Patentnummer
US07294650B2

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