HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
1-Sulfonylurea → N-({[4-(6-amino-7-fluoro-1-oxoisoquinolin-2(1H)-yl)phenyl]amino}carbonyl)-5-cyanothiophene-2-sulfonamide
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 1-Sulfonylurea | HCID 11819083 | — |
| Edukt | 5-Cyanothiophene-2-sulfonamide | HCID 22019526 | — |
| Edukt | [2-(4-Amino-phenyl)-7-fluoro-1-oxo-1,2-dihydro-isoquinolin-6-yl]-methyl-carbamic acid tert-butyl ester | HCID 58998471 | — |
| Produkt | N-({[4-(6-amino-7-fluoro-1-oxoisoquinolin-2(1H)-yl)phenyl]amino}carbonyl)-5-cyanothiophene-2-sulfonamide | HCID 69145254 | — |
Reaktionsschritte
An analogous sulfonylurea coupling and de-protection procedure to that described in Example 29 was performed on [2-(4-Amino-phenyl)-7-fluoro-1-oxo-1,2-dihydro-isoquinolin-6-yl]-methyl-carbamic acid tert-butyl ester (Example 9) and 5-cyanothiophene-2-sulfonamide to give N-({[4-(6-amino-7-fluoro-1-oxoisoquinolin-2(1H)-yl)phenyl]amino}carbonyl)-5-cyanothiophene-2-sulfonamide. ES-MS (M+H)+=498.1.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07294635B2 |
| Quelldatensatz | uspto-grants-2007_11 |
| ORD ID | ord-6fc69de384d84036a81458b101a1a187 |
| Quellennotiz | uspto-grants-2007_11 |