Acetyl chloride → Acetic acid, (2-fluoro-5-nitrophenyl)methyl ester

HRID 1593061Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1593061
[F:1][C:2]1[CH:9]=[CH:8][C:7]([N+:10]([O-:12])=[O:11])=[CH:6][C:3]=1[CH2:4][OH:5].C(N(CC)CC)C.[C:20](Cl)(=[O:22])[CH3:21]>ClCCl.C(OCC)(=O)C>[F:1][C:2]1[CH:9]=[CH:8][C:7]([N+:10]([O-:12])=[O:11])=[CH:6][C:3]=1[CH2:4][O:5][C:20](=[O:22])[CH3:21]

Komponenten

6

Edukt 3

HCID 6367Acetyl chlorideHCID 8471TriethylamineHCID 4437169(2-Fluoro-5-nitrophenyl)methanol

Produkt 1

HCID 58998466Acetic acid, (2-fluoro-5-nitrophenyl)methyl ester

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6344DichloromethaneLösungsmittelHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

To a solution of 2-fluoro-5-nitrobenzyl alcohol (1 g, 5.84 mmol) in 5 mL dichloromethane and triethylamine (0.81 ml, 5.84 mmol), was added acetyl chloride (0.415 ml, 1 eq) dropwise. The solution was stirred at room temperature for 12 hours, diluted with ethyl acetate and extracted with brine. Combine organic layers was dried over sodium sulfate, concentrated in vacuo to give acetic acid 2-fluoro-5-nitro-benzyl ester.

Aufarbeitung

  1. extractionextracted with brine
  2. dry with materialCombine organic layers was dried over sodium sulfate
  3. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-3073f91f13654132910e07b6f1ce6d29
Quelldatensatz
uspto-grants-2007_11
Patentnummer
US07294635B2

Notizen zur Reaktion

Wird geladen…