Sodium Hydroxide → 2-(2-Chlorophenyl)-5-methyl-1H-imidazole-4-carboxylic acid

HRID 1593132Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1593132
C([O:3][C:4]([C:6]1[N:7]=[C:8]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[Cl:18])[NH:9][C:10]=1[CH3:11])=[O:5])C.[OH-].[Na+]>C(O)C>[Cl:18][C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=1[C:8]1[NH:9][C:10]([CH3:11])=[C:6]([C:4]([OH:5])=[O:3])[N:7]=1

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 43445075HCID 43445075, Verbindung

Produkt 1

HCID 434450792-(2-Chlorophenyl)-5-methyl-1H-imidazole-4-carboxylic acidAusbeute 89,9 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Reaktionsbedingungen

Temperatur
95 °C

Versuchsvorschrift

To 11.2 g of 2-(2-chloro-phenyl)-5-methyl-1H-imidazole-4-carboxylic acid ethyl ester in 150 ml of ethanol was added 80 ml of a 2N-NaOH solution and the reaction mixture was stirred at 95° C. for 17 hours. After such time ethanol was removed in vacuo and the remaining aqueous solution was treated with a 2N HCl solution until obtaining pH=3. The precipitate was filtered and dried under high vacuum to yield 9.0 g of a pale yellow powder.

Aufarbeitung

  1. customAfter such time ethanol was removed in vacuo
  2. additionthe remaining aqueous solution was treated with a 2N HCl solution
  3. customuntil obtaining pH=3
  4. filtrationThe precipitate was filtered
  5. customdried under high vacuum

Quellen und Nachweise

ORD-Eintrag
ord-53cac2380de240f2ac157ea66b146f6b
Quelldatensatz
uspto-grants-2007_11
Patentnummer
US07294644B2

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