Methyl acetoacetate → Cyclohexylmethyl-5-(2,5-difluoro-phenyl)-2-methyl-1H-pyrrole-3-carboxylic acid ((1RS,2RS)-2-hydroxy-cyclohexylmethyl)-amide

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	Methyl acetoacetate	HCID 7757	—
Edukt	trans-2-Aminomethyl-1-cyclohexanol	HCID 2724658	—
Edukt	2-Bromo-1-(2,5-difluorophenyl)ethanone	HCID 2778264	—
Produkt	Cyclohexylmethyl-5-(2,5-difluoro-phenyl)-2-methyl-1H-pyrrole-3-carboxylic acid ((1RS,2RS)-2-hydroxy-cyclohexylmethyl)-amide	HCID 72485423	—

Reaktionsschritte

The title compound was synthesized in analogy to Example 68, using 3-oxo-butyric acid methyl ester as compound of formula R, 2-bromo-1-(2,5-difluorophenyl)-ethanone as compound of formula S, c-cyclohexyl-methylamine as R3—(CH2)m—NH2 and trans-2-aminomethyl-1-cyclohexanol as R1R2NH, MS (ISP) 445.5 (M+H)+.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US07294644B2
Quelldatensatz	uspto-grants-2007_11
ORD ID	ord-37f56cae94e24016b2cb745ac3f7ba1b
Quellennotiz	uspto-grants-2007_11