Aluminium lithium hydride → 1-[(3S)-6-Fluoro-2,3,4,9-tetrahydro-1H-carbazol-3-yl]methanamine
Reaktionsgleichung
[F:1][C:2]1[CH:3]=[C:4]2[C:12](=[CH:13][CH:14]=1)[NH:11][C:10]1[CH2:9][CH2:8][C@H:7]([C:15]([NH2:17])=O)[CH2:6][C:5]2=1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>C1COCC1>[F:1][C:2]1[CH:3]=[C:4]2[C:12](=[CH:13][CH:14]=1)[NH:11][C:10]1[CH2:9][CH2:8][C@H:7]([CH2:15][NH2:17])[CH2:6][C:5]2=1Komponenten
Reaktionsbedingungen
- Temperatur
- 2.5 °C
Versuchsvorschrift
(3S)-6-Fluoro-2,3,4,9-tetrahydro-1H-carbazole-3-carboxamide (34.7 g, 150 mmol), was dissolved in 1 L of dry THF, and to the solution were added 300 ml of 1N lithium aluminum hydride in THF. The resulting solution, turning into suspension, was refluxed at vigorous stirring for 1 hr, completion checked by HPLC. The resulting suspension was cooled to 0-5° C., and quenched very slowly with the saturated solution of sodium potassium tartrate (Rochelle salt). The temperature was initially kept below 15° C., then let up to the ambient; 125 ml of the salt solution were added, while the solids in the suspension became crystalline and easily filterable. The reaction mixture was filtered through paper, the filtrate dried over sodium sulfate, evaporated, crystallized from MTBE, dried in the oven to give 26.9 g (82%) of the title compound as white crystals, mp: 121-123° C.
Aufarbeitung
- temperaturewas refluxed
- customquenched very slowly with the saturated solution of sodium potassium tartrate (Rochelle salt)
- customwas initially kept below 15° C.
- addition125 ml of the salt solution were added, while the solids in the suspension
- filtrationThe reaction mixture was filtered through paper
- dry with materialthe filtrate dried over sodium sulfate
- customevaporated
- customcrystallized from MTBE
- customdried in the oven
Quellen und Nachweise
- ORD-Eintrag
- ord-5a9e0e7367f747e5882b103b38530704
- Quelldatensatz
- uspto-grants-2007_11
- Patentnummer
- US07297704B2
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