Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | Acetic Acid | HCID 176 | — |
| Edukt | Sodium Acetate | HCID 517045 | — |
| Edukt | Benzenediazonium, 4-chloro-, hexafluorophosphate(1-) (1:1) | HCID 2723983 | — |
| Edukt | 2-Amino-4-chloro-6-neopentylpyrimidine | HCID 22274982 | — |
| Katalysator | Zinc | HCID 23994 | — |
| Lösungsmittel | Water | HCID 962 | — |
| Lösungsmittel | Water ethanol | HCID 19096565 | — |
| Produkt | 4-Chloro-2,5-diamino-6-neopentyl-pyrimidine | HCID 22274946 | — |
Reaktionsschritte
A mixture of 2-amino-4-chloro-6-neopentylpyrimidine (1 mmol), sodium acetate (14 mmol), acetic acid (86 mmol), and 4-chlorobenzene-diazonium hexafluorophosphate (1.15 mmol) in water was stirred at 25° C. for 12 h. Extraction and evaporation gave a yellow solid which was treated with zinc dust (10 mmol) and acetic acid (5.54 mmol) in EtOH-H2O at 80° C. for 1 h. Extraction and chromatography gave 4-chloro-2,5-diamino-6-neopentyl-pyrimidine as a yellow solid. TLC: Rf=0.25, 50% EtOAc-hexane.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patentnummer | US06284748B1 |
|---|
| Quelldatensatz | uspto-grants-2001_09 |
|---|
| ORD ID | ord-92df3c8e89314e2e820f1a90cd808ab1 |
|---|
| Quellennotiz | uspto-grants-2001_09 |
|---|
