6-Methoxy-2-naphthaldehyde → HCID 178440904, Verbindung

HRID 1594945

Reaktionsgleichung

Reaktionsgleichung von HRID 1594945
[Mg:1].C(C1C=C([Br:12])C=CC=1)=C(C)C.CO[C:15]1[CH:24]=[CH:23][C:22]2[C:17](=C[CH:19]=[C:20]([CH:25]=O)[CH:21]=2)[CH:16]=1>C1COCC1>[CH:21]([C:22]1[CH:17]=[C:16]([Mg:1][Br:12])[CH:15]=[CH:24][CH:23]=1)=[C:20]([CH3:25])[CH3:19]

Komponenten

5

Edukt 3

HCID 769916-Methoxy-2-naphthaldehydeHCID 5462224MagnesiumHCID 217068361-Bromo-3-(2-methyl-1-propenyl)benzene

Produkt 1

HCID 178440904HCID 178440904, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To a suspension of Rieke magnesium (0.12 g, 4.74 mmol; commercially available suspension) in dry THF (4.61 mL) was added neat 3-(iso-buten-1-yl)-phenylbromide (1.0 g, 4.74 mmol) at such a rate as to maintain a steady reflux. After the arylbromide was completely added, the reaction was refluxed under nitrogen for 0.5 hours. The solution was allowed to settle for 18 hours and the supernatant was determined to have a 0.56 m titer for active grignard by tritrating a known quantity of 2-methoxynaphthalene-6-carboxaldehyde.

Aufarbeitung

  1. temperatureto maintain a steady reflux
  2. temperaturethe reaction was refluxed under nitrogen for 0.5 hours

Quellen und Nachweise

ORD-Eintrag
ord-465df1866a874a6884707d2ab3413212
Quelldatensatz
uspto-grants-2001_09
Patentnummer
US06284796B1

Verknüpfte Notizen

Wird geladen…