Benzylamine → HCID 21704006, Verbindung

HRID 1595318Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1595318
[CH:1]1([C:7](=O)[C:8](=[N:16]O)[C:9]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH2:19]([NH2:26])[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>C1C=CC=CC=1>[CH:1]1([C:7]2[NH:26][C:19]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)=[N:16][C:8]=2[C:9]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Komponenten

4

Edukt 2

HCID 7504BenzylamineHCID 178451306HCID 178451306, Verbindung

Produkt 1

HCID 21704006HCID 21704006, VerbindungAusbeute 27,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 241BenzeneLösungsmittel

Versuchsvorschrift

tert-Butyl 3-cyclohexyl-2-hydroxyimino-3-oxopropionate (2.6 g) and benzylamine (2.1 g) were dissolved in benzene (50 ml), and the mixture was refluxed under heating for 16 hr. The solvent was concentrated under reduced pressure. The obtained residue was purified by silica gel chromatography (chloroform:ethyl acetate=8:1) to give tert-butyl 5-cyclohexyl-2-phenylimidazole-4-carboxylate (0.90 g), melting point 222-223° C.

Aufarbeitung

  1. temperaturethe mixture was refluxed
  2. temperatureunder heating for 16 hr
  3. concentrationThe solvent was concentrated under reduced pressure
  4. customThe obtained residue was purified by silica gel chromatography (chloroform:ethyl acetate=8:1)

Quellen und Nachweise

ORD-Eintrag
ord-2d2ec05359ab417f9b6a7f3bc42bc553
Quelldatensatz
uspto-grants-2001_09
Patentnummer
US06288061B1

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