Quinolin-3-ylmethanamine → HCID 178470221, Verbindung

HRID 1595332Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1595332
O[N:2]=[C:3]([C:9]([C:11]1[CH:16]=[CH:15][C:14]([CH3:17])=[CH:13][CH:12]=1)=O)[C:4]([O:6][CH2:7][CH3:8])=[O:5].[NH2:18][CH2:19][C:20]1[CH:21]=[N:22][C:23]2[C:28]([CH:29]=1)=[CH:27][CH:26]=[CH:25][CH:24]=2>>[CH3:17][C:14]1[CH:15]=[CH:16][C:11]([C:9]2[NH:18][C:19]([C:20]3[CH:21]=[N:22][C:23]4[C:28]([CH:29]=3)=[CH:27][CH:26]=[CH:25][CH:24]=4)=[N:2][C:3]=2[C:4]([O:6][CH2:7][CH3:8])=[O:5])=[CH:12][CH:13]=1

Komponenten

3

Edukt 2

HCID 6483745Quinolin-3-ylmethanamineHCID 178472891HCID 178472891, Verbindung

Produkt 1

HCID 178470221HCID 178470221, VerbindungAusbeute 43,5 %

Versuchsvorschrift

Ethyl 2-hydroxyimino-3-(4-methylphenyl)-3-oxopropionate (10.6 g) and 3-aminomethylquinoline (8.5 g) were reacted and treated in the same manner as in Starting Material Synthetic Example 1 to give ethyl 5-(4-methylphenyl)-2-(3-quinolyl)imidazole-4-carboxylate (7.0 g). 6.7 g therefrom was dissolved in ethyl alcohol (135 ml), and the mixture was reacted and treated in the same manner as in Starting Material Synthetic Example 2 to give 5-(4-methylphenyl)-2-(3-quinolyl)imidazole-4-carboxylic acid (2.5 g), melting point 224° C. (decomposition).

Aufarbeitung

  1. additiontreated in the same manner as

Quellen und Nachweise

ORD-Eintrag
ord-002db9c56baf4b52ba665f1e826830ef
Quelldatensatz
uspto-grants-2001_09
Patentnummer
US06288061B1

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