1-Naphthalenemethanamine → Ethyl 5-(4-chlorophenyl)-2-(1-naphthyl)imidazole-4-carboxylate

HRID 1595333

Reaktionsgleichung

Reaktionsgleichung von HRID 1595333
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=O)[C:9](=[N:15]O)[C:10]([O:12][CH2:13][CH3:14])=[O:11])=[CH:4][CH:3]=1.[NH2:18][CH2:19][C:20]1[C:29]2[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=2)[CH:23]=[CH:22][CH:21]=1>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[NH:18][C:19]([C:20]3[C:29]4[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=4)[CH:23]=[CH:22][CH:21]=3)=[N:15][C:9]=2[C:10]([O:12][CH2:13][CH3:14])=[O:11])=[CH:4][CH:3]=1

Komponenten

3

Edukt 2

HCID 83551-NaphthalenemethanamineHCID 178472894HCID 178472894, Verbindung

Produkt 1

HCID 178470176Ethyl 5-(4-chlorophenyl)-2-(1-naphthyl)imidazole-4-carboxylateAusbeute 44,8 %

Versuchsvorschrift

Ethyl 3-(4-chlorophenyl)-2-hydroxyimino-3-oxopropionate (10.0 g) and 1-aminomethylnaphthalene (7.0 g) were reacted and treated in the same manner as in Starting Material Synthetic Example 1 to give ethyl 5-(4-chlorophenyl)-2-(1-naphthyl)imidazole-4-carboxylate (6.6 g). 6.0 g therefrom was dissolved in ethyl alcohol (120 ml), and 1 M sodium hydroxide solution (45 ml) was added. The reaction mixture was reacted and treated in the same manner as in Starting Material Synthetic Example 2 to give 5-(4-chlorophenyl)-2-(1-naphthyl)-imidazole-4-carboxyic acid (4.1 g), melting point 210° C. (decomposition).

Aufarbeitung

  1. additiontreated in the same manner as

Quellen und Nachweise

ORD-Eintrag
ord-fa1a7e6a55af4c2282dfb07182fe9dc9
Quelldatensatz
uspto-grants-2001_09
Patentnummer
US06288061B1

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