4-Dimethylaminomethylbenzylamine → HCID 178470187, Verbindung

HRID 1595379

Reaktionsgleichung

Reaktionsgleichung von HRID 1595379
[CH3:1][N:2]([CH2:4][C:5]1[CH:10]=[CH:9][C:8]([CH2:11][NH2:12])=[CH:7][CH:6]=1)[CH3:3].[Cl:13][C:14]1[CH:19]=[CH:18][C:17]([C:20](=O)[C:21](=[N:27]O)[C:22]([O:24][CH2:25][CH3:26])=[O:23])=[CH:16][CH:15]=1>N1C=CC=CC=1>[Cl:13][C:14]1[CH:19]=[CH:18][C:17]([C:20]2[NH:12][C:11]([C:8]3[CH:9]=[CH:10][C:5]([CH2:4][N:2]([CH3:3])[CH3:1])=[CH:6][CH:7]=3)=[N:27][C:21]=2[C:22]([O:24][CH2:25][CH3:26])=[O:23])=[CH:16][CH:15]=1

Komponenten

4

Edukt 2

HCID 1937144-DimethylaminomethylbenzylamineHCID 178472894HCID 178472894, Verbindung

Produkt 1

HCID 178470187HCID 178470187, VerbindungAusbeute 39,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1049PyridineLösungsmittel

Versuchsvorschrift

4-(Dimethylaminomethyl)phenylmethylamine (11.7 g) and ethyl 3-(4-chlorophenyl)-2-hydroxyimino-3-oxopropionate (15.1 g) were dissolved in pyridine (220 ml) and the solution was refluxed under heating for 12 hr. The solvent was concentrated under reduced pressure and the obtained residue was subjected to silica gel column chromatography to give the objective ethyl 5-(4-chlorophenyl)-2-[4-(dimethylaminomethyl)phenyl]imidazole-4-carboxylate (9.0 g), melting point 175-176° C.

Aufarbeitung

  1. temperaturethe solution was refluxed
  2. temperatureunder heating for 12 hr
  3. concentrationThe solvent was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-8990023815794cd68951d6363c30363a
Quelldatensatz
uspto-grants-2001_09
Patentnummer
US06288061B1

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