Trichloroacetic Acid → 2,2,2-Trichloro-1,1-di(2,3,4,5,6-pentafluorophenyl)-1-ethanol

HRID 1595998

Reaktionsgleichung

Reaktionsgleichung von HRID 1595998
[F:1][C:2]1[C:7]([C:8](=[O:20])[C:9]2[C:14]([F:15])=[C:13]([F:16])[C:12]([F:17])=[C:11]([F:18])[C:10]=2[F:19])=[C:6]([F:21])[C:5]([F:22])=[C:4]([F:23])[C:3]=1[F:24].[Cl:25][C:26]([Cl:31])([Cl:30])C(O)=O.FF.C([O-])(=O)C=C>CO.CN(C)P(N(C)C)(N(C)C)=O>[Cl:25][C:26]([Cl:31])([Cl:30])[C:8]([C:9]1[C:10]([F:19])=[C:11]([F:18])[C:12]([F:17])=[C:13]([F:16])[C:14]=1[F:15])([C:7]1[C:2]([F:1])=[C:3]([F:24])[C:4]([F:23])=[C:5]([F:22])[C:6]=1[F:21])[OH:20]

Komponenten

7

Edukt 4

HCID 6421Trichloroacetic AcidHCID 24524FluorineHCID 25188AcrylateHCID 70068Decafluorobenzophenone

Produkt 1

HCID 226252562,2,2-Trichloro-1,1-di(2,3,4,5,6-pentafluorophenyl)-1-ethanol

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittel2×HCID 12679HexamethylphosphoramideLösungsmittel

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

A mixture of 4.9 g of decafluorobenzophenone and 2.7 g of trichloroacetic acid was added to 15 mL of hexamethylphosphoramide. The stirred reaction mixture was maintained at about 0° C. for about 2 hours and then allowed to warm to room temperature and continue stirring at ambient temperature for the next 15 hours. The reaction mixture was characterized by GC and fluorine NMR to show a conversion of approximately 20% to the desired carbinol. This carbinol can be converted to the corresponding acrylate by methods previously described (cf. Example 24).

Aufarbeitung

  1. customThe stirred reaction mixture
  2. temperatureto warm to room temperature

Quellen und Nachweise

ORD-Eintrag
ord-c84ac2dbbfd3438ea54fd87743b97984
Quelldatensatz
uspto-grants-2001_09
Patentnummer
US06288266B1

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