Methyl Bromide → 2-Bromo-6-ethoxynaphthalene

HRID 1596119

Reaktionsgleichung

Reaktionsgleichung von HRID 1596119
Br[CH3:2].[Br:3][C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][CH:13]=1)[CH:10]=[C:9](O)[CH:8]=[CH:7]2.[C:15](=[O:18])([O-])[O-].[K+].[K+]>CC(C)=O>[Br:3][C:4]1[CH:13]=[CH:12][C:11]2[C:6](=[CH:7][CH:8]=[C:9]([O:18][CH2:15][CH3:2])[CH:10]=2)[CH:5]=1

Komponenten

5

Edukt 3

HCID 6323Methyl BromideHCID 11430Potassium CarbonateHCID 271446-Bromo-2-naphthalenol

Produkt 1

HCID 2368582-Bromo-6-ethoxynaphthalene

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

This experimental procedure is an O-alkylation. A solution of bromomethane (48.90 g, 0.45 mol) is added dropwise to a stirred refluxing mixture of 6-Bromo-2-naphthol (40.00 g, 0.18 mol) and potassium carbonate (63.00 g, 0.46 mol) in acetone. The stirred mixture is heated under reflux for 24 hours (ie until glc analysis reveals a complete reaction). The potassium carbonate is filtered off, water is added to filtrate and the product is recrystallised from ethanol to give a yield of 43.92 g (97%).

Aufarbeitung

  1. temperaturerefluxing
  2. temperatureThe stirred mixture is heated
  3. temperatureunder reflux for 24 hours (ie until glc analysis
  4. customa complete reaction)
  5. filtrationThe potassium carbonate is filtered off
  6. additionwater is added to filtrate
  7. customthe product is recrystallised from ethanol
  8. customto give a yield of 43.92 g (97%)

Quellen und Nachweise

ORD-Eintrag
ord-add5e0c5cb664018a2112c8f826da0b9
Quelldatensatz
uspto-grants-2001_09
Patentnummer
US06291034B1

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