Sodium Hydroxide → HCID 21701683, Verbindung

Reaktionsgleichung

Br.[N:2]1([NH:8][C:9](=[O:17])[C:10]2[CH:15]=[CH:14][C:13]([F:16])=[CH:12][CH:11]=2)[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1.[OH-].[Na+].[CH:20]1([C:23](Cl)=[O:24])[CH2:22][CH2:21]1>O1CCOCC1>[CH:20]1([C:23]([N:5]2[CH2:4][CH2:3][N:2]([NH:8][C:9](=[O:17])[C:10]3[CH:15]=[CH:14][C:13]([F:16])=[CH:12][CH:11]=3)[CH2:7][CH2:6]2)=[O:24])[CH2:22][CH2:21]1

Komponenten

Versuchsvorschrift

To a solution of N-piperazinyl-p-fluorobenzamide hydrobromide (500 mg) in 1N aqueous solution of sodium hydroxide (5 ml) and dioxane (5 ml) was added cyclopropanecarbonyl chloride (0.3 ml) at ambient temperature, and the solution was stirred at (he same temperature for 2 hours. After removal of the solvent in vacuo, the residue was dissolved into ethyl acetate and washed with brine (×2). The organic layer was separated, dried over magnesium sulfate, and concentrated. The residue was recrystallized from 20% ethanol-water to give N-(4-cyclopropanecarbonyl-1-piperazinyl)-p-fluorobenzamide (0.20 g).