Potassium Carbonate → 3-[3-[4-(2-Aminothiazol-4-yl)-4-phenylpiperid-1-yl-]propyl]-1-benzoyl-3-(3,4-dichlorophenyl)perhydroazepine dihydrochloride

HRID 1597091

Reaktionsgleichung

Reaktionsgleichung von HRID 1597091
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([C:7]2([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]2)[N:6]=1.[C:19]([N:27]1[CH2:33][CH2:32][CH2:31][CH2:30][C:29]([C:42]2[CH:47]=[CH:46][C:45]([Cl:48])=[C:44]([Cl:49])[CH:43]=2)([CH2:34][CH2:35][CH2:36]OS(C)(=O)=O)[CH2:28]1)(=[O:26])[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1.C([O-])([O-])=O.[K+].[K+]>CN(C=O)C.C(#N)C>[ClH:48].[ClH:48].[NH2:1][C:2]1[S:3][CH:4]=[C:5]([C:7]2([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)[CH2:8][CH2:9][N:10]([CH2:36][CH2:35][CH2:34][C:29]3([C:42]4[CH:47]=[CH:46][C:45]([Cl:48])=[C:44]([Cl:49])[CH:43]=4)[CH2:30][CH2:31][CH2:32][CH2:33][N:27]([C:19](=[O:26])[C:20]4[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=4)[CH2:28]3)[CH2:11][CH2:12]2)[N:6]=1

Komponenten

5

Edukt 3

HCID 11430Potassium CarbonateHCID 217029661-Benzoyl-3-(3,4-dichlorophenyl)-3-[3-(methanesulfonyloxy)propyl]-perhydroazepineHCID 227417264-(2-Aminothiazol-4-yl)-4-phenylpiperidine

Produkt 1

HCID 227417193-[3-[4-(2-Aminothiazol-4-yl)-4-phenylpiperid-1-yl-]propyl]-1-benzoyl-3-(3,4-dichlorophenyl)perhydroazepine dihydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 21891449acetonitrile N,N-dimethylformamideLösungsmittel

Versuchsvorschrift

This compound is prepared by the procedure described in step D of EXAMPLE 13, starting from 0.77 g of 4-(2-aminothiazol-4-yl)-4-phenylpiperidine (compound of PREPARATION 1.4 in the form of the free base), 1.2 g of the compound obtained in step C of EXAMPLE 13 and 1.2 g of K2CO3 in 20 ml of a DMF/acetonitrile mixture (50/50; v/v). This gives 0.8 g of the expected product after crystallization from AcOEt, m.p.=178° C.

Aufarbeitung

  1. customThis compound is prepared by the procedure
  2. customThis gives 0.8 g of the expected product after crystallization from AcOEt, m.p.=178° C.

Quellen und Nachweise

ORD-Eintrag
ord-5bdcc95169ea4b5db4f585a85b871412
Quelldatensatz
uspto-grants-2001_09
Patentnummer
US06291672B1

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