Ethyl bromoacetate → 1-{3-[(4'-Fluoro[1,1'-biphenyl]-4-yl)sulfonyl]-2-hydroxypropyl}-4,4-dimethyl-2,6-piperidinedione

HRID 1597425

Reaktionsgleichung

Reaktionsgleichung von HRID 1597425
[CH3:1][S:2]([C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=2)=[CH:7][CH:6]=1)(=[O:4])=[O:3].[CH3:18][C:19]1([CH3:27])[CH2:25][C:24](=[O:26])[NH:23][C:21](=[O:22])[CH2:20]1.Br[CH2:29][C:30](OCC)=[O:31]>>[F:17][C:14]1[CH:15]=[CH:16][C:11]([C:8]2[CH:7]=[CH:6][C:5]([S:2]([CH2:1][CH:30]([OH:31])[CH2:29][N:23]3[C:24](=[O:26])[CH2:25][C:19]([CH3:27])([CH3:18])[CH2:20][C:21]3=[O:22])(=[O:4])=[O:3])=[CH:10][CH:9]=2)=[CH:12][CH:13]=1

Komponenten

4

Edukt 3

HCID 7748Ethyl bromoacetateHCID 142924,4-Dimethylpiperidine-2,6-dioneHCID 160868644-(4'-Fluorophenyl)-phenyl methyl sulfone

Produkt 1

HCID 217000651-{3-[(4'-Fluoro[1,1'-biphenyl]-4-yl)sulfonyl]-2-hydroxypropyl}-4,4-dimethyl-2,6-piperidinedione

Versuchsvorschrift

Reaction of 4-(4′-fluorophenyl)-phenyl methyl sulfone with ethyl 3,3-dimethylglutarimideacetate (prepared from 3,3-Dimethylglutarimide and ethyl bromoacetate (as in Example 120A) following the procedures of Example 126A, followed by reduction as described in Example 126B afforded the two title products which were chromatographically separated to give the desired products.

Aufarbeitung

  1. customafforded the two title products which
  2. customwere chromatographically separated

Quellen und Nachweise

ORD-Eintrag
ord-143eb7e78acf4da381a50e842631a733
Quelldatensatz
uspto-grants-2001_09
Patentnummer
US06294573B1

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