Methyl iodide → 3-(2,6-Dichloro-4-trifluoromethylphenyl)-1-methyl-5-methylsulfenylpyrazole

HRID 1598512Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1598512
[Cl:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[C:4]([Cl:12])[C:3]=1[C:13]1[CH:17]=[C:16]([SH:18])[N:15]([CH3:19])[N:14]=1.CI.[C:22](=O)([O-])[O-].[K+].[K+]>C(#N)C>[Cl:1][C:2]1[CH:7]=[C:6]([C:8]([F:9])([F:11])[F:10])[CH:5]=[C:4]([Cl:12])[C:3]=1[C:13]1[CH:17]=[C:16]([S:18][CH3:22])[N:15]([CH3:19])[N:14]=1

Komponenten

5

Edukt 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 178481742HCID 178481742, Verbindung

Produkt 1

HCID 189294193-(2,6-Dichloro-4-trifluoromethylphenyl)-1-methyl-5-methylsulfenylpyrazoleAusbeute 97,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

A suspension of 0.5 g of 3-(2,6-dichloro-4-trifluoromethylphenyl)-5-mercapto-1-methylpyrazole (2), 2.3 g of methyl iodide and 0.4 g of anhydrous potassium carbonate in 10 ml of acetonitrile was refluxed overnight with stirring. The reaction mixture was cooled to room temperature and filtered through Celite, and the filtrate was concentrated under reduced pressure. The residue was purified by chromatography on silica gel to obtain 0.51 g of the desired product in the form of white crystals.

Aufarbeitung

  1. temperaturewas refluxed overnight
  2. filtrationfiltered through Celite
  3. concentrationthe filtrate was concentrated under reduced pressure
  4. customThe residue was purified by chromatography on silica gel

Quellen und Nachweise

ORD-Eintrag
ord-d64ec6771ae04d188fa3214f745faab4
Quelldatensatz
uspto-grants-1998_04
Patentnummer
US05739083

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