Tetrahydrofuran → N-propyl-2,3-dihydro-1H-inden-2-amine

HRID 1598564Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1598564
[H-].[Al+3].[Li+].[H-].[H-].[H-].C([CH:11]1[CH2:19][C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[CH:12]1N)(=O)CC.[Cl-].[NH4+:22].O1C[CH2:26][CH2:25][CH2:24]1>>[CH2:24]([NH:22][CH:11]1[CH2:12][C:13]2[C:18](=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH2:19]1)[CH2:25][CH3:26]

Komponenten

5

Edukt 4

HCID 8028Tetrahydrofuran2×HCID 25517Ammonium ChlorideHCID 21226445Aluminium lithium hydride2×HCID 543218082-Propionyl aminoindane

Produkt 1

HCID 17221237N-propyl-2,3-dihydro-1H-inden-2-amine

Versuchsvorschrift

In 100 ml of tetrahydrofuran was suspended 5.7 g of lithium aluminum hydride, and to the suspension was added dropwise 18.9 g of 2-propionyl aminoindane dissolved in 150 ml of tetrahydrofuran. The mixture was refluxed under heating for 2 hours. After cooling, excessive lithium aluminum hydride was treated with a saturated ammonium chloride aqueous solution, and insolubles were removed by filtration. The filtrate was condensed, and chloroform was added to the residue. After the mixture was washed with 10 water and dried, the solvent was removed to obtain 17.5 g of 2-propylaminoindane.

Aufarbeitung

  1. temperatureThe mixture was refluxed
  2. temperatureunder heating for 2 hours
  3. temperatureAfter cooling
  4. customwere removed by filtration
  5. customcondensed, and chloroform
  6. additionwas added to the residue
  7. washAfter the mixture was washed with 10 water
  8. customdried
  9. customthe solvent was removed

Quellen und Nachweise

ORD-Eintrag
ord-968c44bf8df84e558d1424ad845337e4
Quelldatensatz
uspto-grants-1998_04
Patentnummer
US05739132

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