Toluene → 2,2-Difluoro-4-pentenoyl chloride

HRID 1599103

Reaktionsgleichung

Reaktionsgleichung von HRID 1599103
[F:1][C:2]([F:9])([CH2:6][CH:7]=[CH2:8])[C:3](O)=[O:4].[Cl:10]CCl.C1(C)C=CC=CC=1>CN(C)C=O>[F:1][C:2]([F:9])([CH2:6][CH:7]=[CH2:8])[C:3]([Cl:10])=[O:4]

Komponenten

5

Edukt 3

HCID 1140TolueneHCID 6344DichloromethaneHCID 119546562,2-Difluoro-4-pentenoic acid

Produkt 1

HCID 136650492,2-Difluoro-4-pentenoyl chloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

For example, 2,2-difluoro-4-pentenoic acid 8c is contacted with about 1.0 to 1.5 molar equivalents of an appropriate chlorinating agent. The reaction is carried out in a suitable solvent, such as dichloromethane, toluene or dimethylformamide. The reaction is carried out at a temperature of from about 20° C. to about 35° C. and generally requires about 4 to 24 hours. The product, 2,2-difluoro-4-pentenoyl chloride 8a, can be isolated by fractional distillation and purified by techniques well known in the art, such as chromatography.

Aufarbeitung

  1. customis carried out at a temperature of from about 20° C. to about 35° C. and generally requires about 4 to 24 hours

Quellen und Nachweise

ORD-Eintrag
ord-49d4c16ccf34401cb8dac9db188336a3
Quelldatensatz
uspto-grants-1998_04
Patentnummer
US05739354

Verknüpfte Notizen

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