HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Tributylphosphine → 5-[4-(1-Methylindol-2-ylmethoxy)benzyl]-3-triphenylmethylthiazolidine-2,4-dione
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Tributylphosphine | HCID 13831 | — |
| Edukt | 1,1'-(Azodicarbonyl)dipiperidine | HCID 73042 | — |
| Edukt | (1-methyl-1H-indol-2-yl)methanol | HCID 295652 | — |
| Edukt | 5-(4-Hydroxybenzyl)-3-triphenylmethylthiazolidine-2,4-dione | HCID 2818126 | — |
| Lösungsmittel | Benzene | HCID 241 | — |
| Produkt | 5-[4-(1-Methylindol-2-ylmethoxy)benzyl]-3-triphenylmethylthiazolidine-2,4-dione | HCID 23298332 | 46,6% |
Reaktionsschritte
A procedure similar to that described in Preparation 4 was repeated, except that 4.30 g of 1-methylindol-2-ylmethanol (prepared as described in Preparation 23), 10.3 g of 5-(4-hydroxybenzyl)-3-triphenylmethylthiazolidine-2,4-dione, 6.65 ml of tributylphosphine, 6.73 g of 1,1'-(azodicarbonyl)dipiperidine and 120 ml of benzene were used, to give 6.28 g of the title compound, melting at 134.3°-136.0° C.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US05739345 |
| Quelldatensatz | uspto-grants-1998_04 |
| ORD ID | ord-f3d0508114f5402bb73145c73bb2bb94 |
| Quellennotiz | uspto-grants-1998_04 |