Imidazole → HCID 18926613, Verbindung

HRID 1600165Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1600165
[CH3:1][N:2]([CH3:16])[CH2:3][C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([N+:13]([O-:15])=[O:14])[CH:11]=2)[NH:6][CH:5]=1.[NH:17]1C=CN=[CH:18]1>C1(C)C(C)=CC=CC=1>[N:2]1([CH2:3][C:4]2[C:12]3[C:7](=[CH:8][CH:9]=[C:10]([N+:13]([O-:15])=[O:14])[CH:11]=3)[NH:6][CH:5]=2)[CH:16]=[CH:18][N:17]=[CH:1]1

Komponenten

4

Edukt 2

HCID 795ImidazoleHCID 18882Indole, 3-((dimethylamino)methyl)-5-nitro-

Produkt 1

HCID 18926613HCID 18926613, VerbindungAusbeute 93,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 7237O-XyleneLösungsmittel

Versuchsvorschrift

A mixture of N,N-dimethyl-5-nitro-1H-indole-3-methanamine (J.Med, Chem, 9, 140,(1966)) (9.10 g) and imidazole (2.96 g) in xylene (120 ml) was heated under reflux for 2.5 hours and then cooled. The solid was filtered off, washed with ether and dried to give the title compound (9.40 g), m.p. 230°-232° C. (from ethyl acetate/methanol). Found: C,59.85; H,4.39; N,22.80. C12H10N4O2 requires: C,59.50; H,4.16; N,23.13%.

Aufarbeitung

  1. temperaturewas heated
  2. temperatureunder reflux for 2.5 hours
  3. temperaturecooled
  4. filtrationThe solid was filtered off
  5. washwashed with ether
  6. customdried

Quellen und Nachweise

ORD-Eintrag
ord-dab7a92d21104d1abe9121c894b2b43a
Quelldatensatz
uspto-grants-1998_04
Patentnummer
US05744488

Notizen zur Reaktion

Wird geladen…