Sodium Hydroxide → (+/-)-1-(2,6-Dimethylbiphenyl-4-yloxy)-4-(3-pyridyl)-2-butanol

HRID 1600963Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1600963
Cl[CH2:2][CH:3]([OH:12])[CH2:4][CH2:5][C:6]1[CH:7]=[N:8][CH:9]=[CH:10][CH:11]=1.[CH3:13][C:14]1[CH:19]=[C:18]([OH:20])[CH:17]=[C:16]([CH3:21])[C:15]=1[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1.[OH-].[Na+]>C(O)C>[CH3:21][C:16]1[CH:17]=[C:18]([O:20][CH2:2][CH:3]([OH:12])[CH2:4][CH2:5][C:6]2[CH:7]=[N:8][CH:9]=[CH:10][CH:11]=2)[CH:19]=[C:14]([CH3:13])[C:15]=1[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1

Komponenten

5

Edukt 3

HCID 14798Sodium HydroxideHCID 218306382,6-Dimethylbiphenyl-4-olHCID 22465338HCID 22465338, Verbindung

Produkt 1

HCID 21830751(+/-)-1-(2,6-Dimethylbiphenyl-4-yloxy)-4-(3-pyridyl)-2-butanolAusbeute 55 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

Prepared according to the method described in Example 24b) from (±)-α-(chloromethyl)-3-pyridinepropanol (0.70 g), 2,6-dimethylbiphenyl-4-ol (0.79 g), ethanol (15 ml) and aqueous sodium hydroxide (1.9 M, 2.5 ml). After work up the residue was purified by column chromatography over silica with ethyl acetate to give the title compound as a solid (0.72 g).

Aufarbeitung

  1. customPrepared
  2. customAfter work up the residue was purified by column chromatography over silica with ethyl acetate

Quellen und Nachweise

ORD-Eintrag
ord-b8a79e300d224738aa69a44045bc9ae2
Quelldatensatz
uspto-grants-1999_11
Patentnummer
US05977105

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