Sodium Hydroxide → 2,5-Dimethyl-3-furoic acid

HRID 1601186

Reaktionsgleichung

Reaktionsgleichung von HRID 1601186
[CH3:1][C:2]1[O:3][C:4]([CH3:12])=[CH:5][C:6]=1[C:7]([O:9]CC)=[O:8].[OH-].[Na+]>C(O)C>[CH3:1][C:2]1[O:3][C:4]([CH3:12])=[CH:5][C:6]=1[C:7]([OH:9])=[O:8]

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 1414573-Furancarboxylic acid, 2,5-dimethyl-, ethyl ester

Produkt 1

HCID 694652,5-Dimethyl-3-furoic acidAusbeute 85,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A mixture of 3.2 g of ethyl 2,5-dimethylfuran-3-carboxylate, 35 ml of ethanol and 20 ml of 2 N sodium hydroxide was stirred at room temperature for 1.5 hours followed by heating under ref lux for an hour. After the reaction mixture was allowed to cool to room temperature, it was concentrated under reduced pressure. The residue was dissolved in water and acidified with diluted sulfuric acid. Precipitated crystals were collected by filtration, washed with water and dried to give 2.27 g of 2,5-dimethylfuran-3-carboxylic acid in a 85% yield.

Aufarbeitung

  1. temperatureby heating under ref lux for an hour
  2. temperatureto cool to room temperature
  3. concentrationit was concentrated under reduced pressure
  4. dissolutionThe residue was dissolved in water
  5. customPrecipitated crystals
  6. filtrationwere collected by filtration
  7. washwashed with water
  8. customdried

Quellen und Nachweise

ORD-Eintrag
ord-0b79ee921d4c4a5da4958c25b9be5b52
Quelldatensatz
uspto-grants-1999_11
Patentnummer
US05977168

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