Glycolic Acid → HCID 10849735, Verbindung

HRID 1601859Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1601859
[NH2:1][C:2]1[C:3]([NH:15][CH3:16])=[N:4][C:5]([S:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[CH:6][CH:7]=1.[C:17]([OH:21])(=O)[CH2:18]O>>[OH:21][CH2:17][C:18]1[N:15]([CH3:16])[C:3]2=[N:4][C:5]([S:8][C:9]3[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=3)=[CH:6][CH:7]=[C:2]2[N:1]=1

Komponenten

3

Edukt 2

HCID 757Glycolic AcidHCID 105137093-Amino-2-methylamino-6-phenylthiopyridine

Produkt 1

HCID 10849735HCID 10849735, Verbindung

Versuchsvorschrift

A procedure similar to that described in Preparation 43 was repeated, except that 2.62. g of 3-amino-2-methylamino-6-phenylthiopyridine (prepared as described in Preparation 89) and 2.58 g of glycolic acid were used, and that the product was purified by column chromatography through silica gel, using a gradient elution method, with mixtures of ethyl acetate and methanol in ratios ranging from 50:1 to 10:1 by volume as the eluent, to give 1.80 g of the title compound, melting at 119-120° C.

Aufarbeitung

  1. customA procedure similar to that described in Preparation 43
  2. customthat the product was purified by column chromatography through silica gel
  3. washa gradient elution method

Quellen und Nachweise

ORD-Eintrag
ord-cb965347e8b44beb8c716c26491254e9
Quelldatensatz
uspto-grants-1999_11
Patentnummer
US05977365

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