Glycolic Acid → 3h-Imidazo[4,5-b]pyridine-2-methanol,3-methyl-5-(1-methylethoxy)-

HRID 1601871Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1601871
[NH2:1][C:2]1[C:3]([NH:12][CH3:13])=[N:4][C:5]([O:8][CH:9]([CH3:11])[CH3:10])=[CH:6][CH:7]=1.[C:14]([OH:18])(=O)[CH2:15]O>>[CH:9]([O:8][C:5]1[N:4]=[C:3]2[N:12]([CH3:13])[C:15]([CH2:14][OH:18])=[N:1][C:2]2=[CH:7][CH:6]=1)([CH3:11])[CH3:10]

Komponenten

3

Edukt 2

HCID 757Glycolic AcidHCID 108212696-Isopropoxy-N2-methylpyridine-2,3-diamine

Produkt 1

HCID 108228683h-Imidazo[4,5-b]pyridine-2-methanol,3-methyl-5-(1-methylethoxy)-Ausbeute 25 %

Versuchsvorschrift

A procedure similar to that described in Preparation 43 was repeated, except that 1.90 g of 3-amino-6-isopropoxy-2-methylaminopyridine (prepared as described in Preparation 101), and 2.39 g of glycolic acid were used, and that the product was purified by column chromatography through silica gel, using a 10:1 by volume mixture of ethyl acetate and methanol, to give 0.58 g of the title compound, melting at 125-127° C.

Aufarbeitung

  1. customA procedure similar to that described in Preparation 43
  2. customthat the product was purified by column chromatography through silica gel
  3. additionby volume mixture of ethyl acetate and methanol

Quellen und Nachweise

ORD-Eintrag
ord-92b518282f784a9a85c1d75e5bc3ffa4
Quelldatensatz
uspto-grants-1999_11
Patentnummer
US05977365

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