1-Azabicyclo[2.2.2]oct-3-yl methanesulfonate → HCID 15663665, Verbindung

Beteiligte Stoffe

Reaktionsschritte

3-Methanesulphonyloxy-1-azabicylo[2.2.2]octane (D8) (2.0 g, 9.7 mmol) and the sodium salt of 5-aminotetrazole (D15) (2.5 g, 2.0 eq) were dissolved in dry DMF (50 ml) and the reaction carried out as for Example 10. The product (E11) isolated from column chromatography was a white crystalline solid (124 mg, 6.6%), which was recrystallised from ether, m.p. 132-134° C.

Herkunft & Nachweise