Hydrochloric Acid → HCID 70102975, Verbindung
Reaktionsgleichung
Br.[C:2]([C:6]1[N:7]=[C:8]([CH2:11][CH2:12][O:13][C:14]2[CH:15]=[C:16]([CH:21]=[CH:22][CH:23]=2)[C:17]([O:19]C)=[O:18])[S:9][CH:10]=1)([CH3:5])([CH3:4])[CH3:3].[ClH:24]>CO>[ClH:24].[C:2]([C:6]1[N:7]=[C:8]([CH2:11][CH2:12][O:13][C:14]2[CH:15]=[C:16]([CH:21]=[CH:22][CH:23]=2)[C:17]([OH:19])=[O:18])[S:9][CH:10]=1)([CH3:5])([CH3:3])[CH3:4]Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Reaktionsbedingungen
- Temperatur
- 60 °C
Versuchsvorschrift
A mixture of methyl 3-[2-(4-tert-butyl-2-thiazolyl)ethoxy]benzoate hydrobromide (102 mg, 0.25 mmol), methanol (1 ml) and 6 N hydrochloric acid (0.5 ml) was stirred at 60° C. for 2 hours, 6 N hydrochloric acid (1 ml) was added, and the mixture was and stirred at 110° C. for 2 hours. The reaction solution was cooled and concentrated under reduced pressure. The resulting solid material was collected by filtration and washed with acetonitrile and diethyl ether in that order to give 3-[2-(4-tert-butyl-2-thiazolyl)ethoxy]benzoic acid hydrochloride (69 mg, 0.20 mmol, 80%).