Glycolide → Lactic acid glycolic acid epsilon-caprolactone

HRID 16030

Reaktionsgleichung

Reaktionsgleichung von HRID 16030
[CH3:1][C@@H:2]1[O:9][C:7](=[O:8])[C@H:6]([CH3:10])[O:5][C:3]1=[O:4].[CH2:11]1[O:18]C(=O)C[O:14][C:12]1=[O:13]>C1(=O)OCCCCC1.C([O-])(=O)CCCCCCC.[Sn+4].C([O-])(=O)CCCCCCC.C([O-])(=O)CCCCCCC.C([O-])(=O)CCCCCCC.C(Cl)(Cl)Cl>[C:3]([OH:5])(=[O:4])[CH:2]([CH3:1])[OH:9].[C:12]([OH:14])(=[O:13])[CH2:11][OH:18].[C:7]1(=[O:8])[O:9][CH2:2][CH2:3][CH2:11][CH2:10][CH2:6]1

Komponenten

6

Edukt 2

HCID 65432GlycolideHCID 107983Lactide, L-

Produkt 1

HCID 69492331Lactic acid glycolic acid epsilon-caprolactone

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 10401epsilon-CAPROLACTONEKatalysatorHCID 9961620Tetrakis(octanoate);tin(4+)KatalysatorHCID 6212ChloroformLösungsmittel

Versuchsvorschrift

A reactor equipped with an exhaust vent and a thermometer was charged with 263 g of L-lactide (reagent, supplied by SIGMA-ALDRICH JAPAN K.K.), 42 g of glycollide (prepared under the same conditions as those in Example 1), 194 g of ε-caprolactone (reagent, supplied by TOKYO CHEMICAL INDUSTRY CO., LTD.) and 0.01 g of tin octanoate (reagent, supplied by SIGMA-ALDRICH JAPAN K.K.) as a catalyst, and the pressure inside the reactor was reduced to 1×10−3 mmHg with a vacuum pump, followed by polymerization at 190° C. for 24 hours. After the reaction, a copolymer was dissolved in chloroform and purified by precipitation in methanol, to give a lactic acid/glycolic acid/ε-caprolactone copolymer.

Aufarbeitung

  1. customA reactor equipped with an exhaust vent
  2. customfollowed by polymerization at 190° C. for 24 hours
  3. customAfter the reaction
  4. custompurified by precipitation in methanol

Quellen und Nachweise

ORD-Eintrag
ord-0d1d811887594b48876707271c6f6132
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07736393B2

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