tert-butyl N-(4-aminobutyl)carbamate → 1-(4-N-Boc-aminobutyl)-1H-pyrrole-2,5-dione

Beteiligte Stoffe

Reaktionsschritte

To a solution of N-BOC-1,4-diaminobutane (8.324 g, 0.044 mol) in dry toluene (50 ml) was added maleic anhydride (4.336 g, 0.044 mol) and the solution heated at reflux under Dean-Stark conditions for two days. The solvent was removed and the residue purified by silica column chromatography eluting with 25-40% ethyl acetate in hexane to give the title compound, 1.461 g, 12%, as a white solid.

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