HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
5-Methoxy-6-(trifluoromethyl)indoline → 5-Methoxy-6-trifluoromethyl-1-[4-(pyridin-4-ylthiomethyl)phenyl Carbamoyl]indoline
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 5-Methoxy-6-(trifluoromethyl)indoline | HCID 11206713 | — |
| Edukt | Benzenamine, 4-[(4-pyridinylthio)methyl]- | HCID 18005148 | — |
| Edukt | Phenylcarbamate | HCID 21896570 | — |
| Produkt | 5-Methoxy-6-trifluoromethyl-1-[4-(pyridin-4-ylthiomethyl)phenyl Carbamoyl]indoline | HCID 18005150 | 64% |
Reaktionsschritte
4-(Pyridin-4-ylthiomethyl)aniline (0.37 g, 1.71 mmol) was converted to the phenylcarbamate and treated with 5-methoxy-6-trifluoromethylindoline (D111) (0.37 g, 1.71 mmol) as in the method of Example 26 to give the title compound (0.5 g, 64%) as a white crystalline solid m.p. 174-5° C.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US05990133 |
| Quelldatensatz | uspto-grants-1999_11 |
| ORD ID | ord-9d08a06f7a7546d8b42c091e0a6c4797 |
| Quellennotiz | uspto-grants-1999_11 |