2-Bromoethanol → (R)-1-Methyl-1,2,3,4-tetrahydroisoquinoline

HRID 1604030Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1604030
[CH3:1][C@@H:2]([NH2:9])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.Br[CH2:11][CH2:12]O>ClCCl>[CH3:1][C@@H:2]1[C:3]2[C:8](=[CH:7][CH:6]=[CH:5][CH:4]=2)[CH2:12][CH2:11][NH:9]1

Komponenten

4

Edukt 2

HCID 108982-BromoethanolHCID 6431891-Phenethylamine, (+)-

Produkt 1

HCID 11084033(R)-1-Methyl-1,2,3,4-tetrahydroisoquinolineAusbeute 85.303,602 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Reaktionsbedingungen

Temperatur
51 °C

Versuchsvorschrift

51.45 g(0.43 mmole) of (R)-(+)-α-methylbenzylamine was dissolved in 52 ml of dichloromethane and 63.78 g(0.51 mmole) of 2-bromoethanol was added thereto. This mixture was stirred at 51° C. for 50 hours to complete the reaction. The reaction solution was concentrated under reduced pressure and the residue was subjected to fractional distillation to obtain 54 g of the title compound having pale yellow color.

Aufarbeitung

  1. customthe reaction
  2. concentrationThe reaction solution was concentrated under reduced pressure
  3. distillationthe residue was subjected to fractional distillation

Quellen und Nachweise

ORD-Eintrag
ord-df70338bc03e4c9dbabd52dcb029ba68
Quelldatensatz
uspto-grants-1999_11
Patentnummer
US05990311

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