Ethyl 4-(2-(10-(Isopropylthio)decanoylamino)phenylthio)butyrate → 4-(2-(11-Carboxyundecanoylamino)phenylthio)butyric acid
Reaktionsgleichung
[NH2:1][C:2]1[C:7](C)=[CH:6][CH:5]=[CH:4][C:3]=1[S:9][CH2:10][CH2:11][CH2:12][C:13]([O:15]CC)=[O:14].[C:18](OC)(=[O:32])[CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][C:29]([O-:31])=[O:30].C(SCCCCCCCCCC(NC1C=CC=CC=1SCCCC(OCC)=O)=O)(C)C>>[C:29]([CH2:28][CH2:27][CH2:26][CH2:25][CH2:24][CH2:23][CH2:22][CH2:21][CH2:20][CH2:19][C:18]([NH:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:9][CH2:10][CH2:11][CH2:12][C:13]([OH:15])=[O:14])=[O:32])([OH:31])=[O:30]Komponenten
4
Versuchsvorschrift
When amine (11) is acylated with acid chloride (7) as per procedure Step (E), and the resultant diester (ethyl 4-(2-(11-carbomethoxyundecanoylamino)phenylthio)butyrate 12 is hydrolyzed in Step I as per procedure (F), the title compound, 13 m.p. 113.5-115° C. is obtained.