Potassium Carbonate → Methyl 6-hydroxymethyl-3-methylquinoline-2-carboxylate

HRID 1604548Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1604548
C([O:4][CH2:5][C:6]1[CH:7]=[C:8]2[C:13](=[CH:14][CH:15]=1)[N:12]=[C:11]([C:16]([O:18][CH2:19]C)=[O:17])[C:10]([CH3:21])=[CH:9]2)(=O)C.C(=O)([O-])[O-].[K+].[K+]>CO>[OH:4][CH2:5][C:6]1[CH:7]=[C:8]2[C:13](=[CH:14][CH:15]=1)[N:12]=[C:11]([C:16]([O:18][CH3:19])=[O:17])[C:10]([CH3:21])=[CH:9]2

Komponenten

4

Edukt 2

HCID 11430Potassium CarbonateHCID 19603481Ethyl 6-acetoxymethyl-3-methylquinoline-2-carboxylate

Produkt 1

HCID 19603207Methyl 6-hydroxymethyl-3-methylquinoline-2-carboxylateAusbeute 5,9 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A mixture of ethyl 6-acetoxymethyl-3-methylquinoline-2-carboxylate (420 mg) and potassium carbonate in methanol was stirred for 30 minutes under ice-cooling. After filtration the filtrate was concentrated and partitioned between ethyl acetate and water. The organic layer was washed with water, dried over magnesium sulfate and concentrated to give methyl 6-hydroxymethyl-3-methylquinoline-2-carboxylate (20 mg).

Aufarbeitung

  1. temperaturecooling
  2. filtrationAfter filtration the filtrate
  3. concentrationwas concentrated
  4. custompartitioned between ethyl acetate and water
  5. washThe organic layer was washed with water
  6. dry with materialdried over magnesium sulfate
  7. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-88db145c2b284e7a8be0441b53a3e69c
Quelldatensatz
uspto-grants-1999_11
Patentnummer
US05994368

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