Sulfuric Acid → HCID 19603840, Verbindung

HRID 1604628Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1604628
[CH2:1]([O:8][C:9]1[CH:10]=[CH:11][C:12]([N+:19]([O-:21])=[O:20])=[C:13]([CH2:15][C:16]([OH:18])=[O:17])[CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.S(=O)(=O)(O)O.[CH:27](O)([CH3:29])[CH3:28]>>[CH2:1]([O:8][C:9]1[CH:10]=[CH:11][C:12]([N+:19]([O-:21])=[O:20])=[C:13]([CH2:15][C:16]([O:18][CH:27]([CH3:29])[CH3:28])=[O:17])[CH:14]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Komponenten

4

Edukt 3

HCID 1118Sulfuric AcidHCID 3776IsopropanolHCID 19603791HCID 19603791, Verbindung

Produkt 1

HCID 19603840HCID 19603840, Verbindung

Versuchsvorschrift

A mixture of 5-benzyloxy-2-nitrophenylacetic acid (4.0 g) and conc. sulphuric acid (0.6 ml) in isopropyl alcohol (40 ml) was stirred under reflux for 1 day. After removal of solvent by evaporation, the resulting residue was dissolved with ethyl acetate. The ethyl acetate extract was washed successively with aqueous sodium hydrogen carbonate solution, water, and brine, and was dried over magnesium sulfate, and concentrated under reduced pressure to give isopropyl 5-benzyloxy-2-nitrophenylacetate (4.20 g).

Aufarbeitung

  1. temperatureunder reflux for 1 day
  2. customAfter removal of solvent
  3. customby evaporation
  4. dissolutionthe resulting residue was dissolved with ethyl acetate
  5. extractionThe ethyl acetate extract
  6. washwas washed successively with aqueous sodium hydrogen carbonate solution, water, and brine
  7. dry with materialwas dried over magnesium sulfate
  8. concentrationconcentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-caa0200444f44ff19a4f554d46e8c6f1
Quelldatensatz
uspto-grants-1999_11
Patentnummer
US05994378

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