Hydrochloric Acid → Pirbuterol Hydrochloride

HRID 1604956Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1604956
[ClH:1].CC1(C)[O:8][C:7]2[CH:9]=[CH:10][C:11]([CH:13]([OH:20])[CH2:14][NH:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[N:12][C:6]=2[CH2:5][O:4]1>CO>[ClH:1].[ClH:1].[OH:4][CH2:5][C:6]1[C:7]([OH:8])=[CH:9][CH:10]=[C:11]([CH:13]([OH:20])[CH2:14][NH:15][C:16]([CH3:18])([CH3:17])[CH3:19])[N:12]=1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 21428405α-[[(1,1-Dimethylethyl)amino]methyl]-2,2-dimethyl-4H-1,3-dioxino[5,4-b]pyridine-6-methanol

Produkt 1

HCID 68658Pirbuterol Hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

To 10 ml. of methanol and 10 ml. of 10% hydrochloric acid is added 227 mg. of 2,2-dimethyl-6-(1-hydroxy-2-t-butylaminoethyl)-4H-pyrido[3,2-d]-1,3-dioxin, and the resulting reaction mixture allowed to stir at room temperature for 1.5 hrs. Removal of the solvents under vacuum at 70° C. provides 230 mg. of the desired product, which is identical by nuclear magnetic resonance spectroscopy to the product in U.S. Pat. No. 3,700,681.

Aufarbeitung

  1. customRemoval of the solvents under vacuum at 70° C.
  2. customprovides 230 mg

Quellen und Nachweise

ORD-Eintrag
ord-8ce32a7bcc354aeaabf688ad27b29157
Quelldatensatz
uspto-grants-1976_04
Patentnummer
US03948919

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