Dichloromethane → HCID 68137584, Verbindung

HRID 1605189Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1605189
[CH3:1][C:2]1([O:8][C:9]([NH:11][C@H:12]([C:20]([OH:22])=[O:21])[CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[O:10])[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1.Cl.[CH3:24][O:25][C:26](=[O:30])[C@H:27]([CH3:29])[NH2:28].C(Cl)Cl>C(N(CC)CC)C>[CH3:1][C:2]1([O:8][C:9]([NH:11][C@H:12]([C:20]([OH:22])=[O:21])[CH2:13][C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=2)=[O:10])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7]1.[CH3:24][O:25][C:26](=[O:30])[C@H:27]([CH3:29])[NH2:28]

Komponenten

5

Edukt 3

HCID 6344DichloromethaneHCID 2733257Alanine methyl ester hydrochlorideHCID 54520100HCID 54520100, Verbindung

Produkt 1

HCID 68137584HCID 68137584, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8471TriethylamineLösungsmittel

Versuchsvorschrift

A solution of 0.67 mM of the hydroxysuccinimide ester of N-(1-methylcyclohexyloxycarbonyl) phenylalanine and 0.70 mM of alanine methyl ester hydrochloride in 10 ml. of methylene chloride is treated with triethylamine until the pH is adjusted to 7.6-8.0. Reaction is stirred six hours and the reaction mixture is washed according to the following procedure: one time with dilute sodium bicarbonate solution; once with 50% saturated sodium chloride solution; once with 0.2 N sulfuric acid saturated with sodium sulfate; and two times with 50% saturated sodium chloride solution. The resulting material is dried over sodium sulfate and the washing procedure repeated. The solvent is removed in vacuo to afford N-(1-methylcyclohexyloxycarbonyl) phenylalanine-alanine methyl ester.

Aufarbeitung

  1. customReaction
  2. washthe reaction mixture is washed
  3. dry with materialThe resulting material is dried over sodium sulfate
  4. customThe solvent is removed in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-cdb3420a54b247efaf2fc0f4e2d209a3
Quelldatensatz
uspto-grants-1976_04
Patentnummer
US03948971

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