Sodium Carbonate → (4-Methyl-6-piperonylamino-2-pyrimidinylthio)acetonitrile

HRID 1605243Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1605243
Cl[C:2]1[CH:7]=[C:6]([CH3:8])[N:5]=[C:4]([S:9][CH2:10][C:11]#[N:12])[N:3]=1.[CH2:13]([NH2:23])[C:14]1[CH:22]=[CH:21][C:20]2[O:19][CH2:18][O:17][C:16]=2[CH:15]=1.C(=O)([O-])[O-].[Na+].[Na+]>C(O)C>[O:19]1[C:20]2[CH:21]=[CH:22][C:14]([CH2:13][NH:23][C:2]3[CH:7]=[C:6]([CH3:8])[N:5]=[C:4]([S:9][CH2:10][C:11]#[N:12])[N:3]=3)=[CH:15][C:16]=2[O:17][CH2:18]1

Komponenten

5

Edukt 3

HCID 10340Sodium CarbonateHCID 75799Benzo-1,3-dioxole-5-methylamineHCID 12228966Acetonitrile, [(4-chloro-6-methyl-2-pyrimidinyl)thio]-

Produkt 1

HCID 12228971(4-Methyl-6-piperonylamino-2-pyrimidinylthio)acetonitrile

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A stirred mixture of 13.93 g. (0.07 mole) of (4-chloro-6-methyl-2-pyrimidinylthio)acetonitrile, 10.5 g. (0.07 mole) of piperonylamine and 7.42 g. (0.07 mole) of sodium carbonate in 100 ml of ethanol was heated under reflux for five hours. The mixture was filtered and the filtrate was cooled in ice. The precipitate thus formed was collected and recrystallized from absolute ethanol to give 15.7 g. of product, m.p. 115°-118°.

Aufarbeitung

  1. additionA stirred mixture of 13.93 g
  2. temperatureunder reflux for five hours
  3. filtrationThe mixture was filtered
  4. temperaturethe filtrate was cooled in ice
  5. customThe precipitate thus formed
  6. customwas collected
  7. customrecrystallized from absolute ethanol
  8. customto give 15.7 g

Quellen und Nachweise

ORD-Eintrag
ord-94ecfe17e6e54d1bb0dedb5b1ad8e602
Quelldatensatz
uspto-grants-1976_04
Patentnummer
US03950339

Notizen zur Reaktion

Wird geladen…