Methyl Isocyanate → N-Methyl-N'-[2-(2-pyrimidylmethylamino)ethyl]urea

Reaktionsgleichung

[N:1]1[CH:6]=[CH:5][CH:4]=[N:3][C:2]=1[CH2:7][NH:8][CH2:9][CH2:10][NH2:11].[CH3:12][N:13]=[C:14]=[O:15]>>[CH3:12][NH:13][C:14]([NH:11][CH2:10][CH2:9][NH:8][CH2:7][C:2]1[N:3]=[CH:4][CH:5]=[CH:6][N:1]=1)=[O:15]

Komponenten

Edukt 2

HCID 12228Methyl Isocyanate

HCID 20557649N-(2-pyrimidylmethyl)ethylenediamine

Produkt 1

HCID 20557658N-Methyl-N'-[2-(2-pyrimidylmethylamino)ethyl]urea

Versuchsvorschrift

By the procedure of Example 24, N-(2-pyrimidylmethyl)ethylenediamine is reacted with methyl isocyanate to give, after concentrating and separating the residue by column chromatography, the title compound.

Aufarbeitung

customto give
concentrationafter concentrating
customseparating the residue by column chromatography

Quellen und Nachweise

ORD-Eintrag: ord-e19c6d6c944d43e3bf0d23d275aab381
Quelldatensatz: uspto-grants-1976_04
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US03950353

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